| Prof. Dr. Axel Klawonn | Director |
| Prof. Dr.-Ing. Gregor Gassner | Vice Director, Scientific Domain 1: Theory of Data and Simulation Science |
| Prof. Dr. Achim Tresch | Vice Director, Scientific Domain 2: Computational Biology and Medicine |
| Prof. Dr. Stefanie Walch-Gassner | Vice Director, Scientific Domain 3: Quantitative Modeling of Complex Physical Systems |
| Prof. Dr. Wolfgang Ketter | Vice Director, Scientific Domain 4: Computational Economics and Social Sciences |
| Prof. Dr. Andreas Witt | Vice Director, Scientific Domain 5: Digital Humanities |
| Prof. Dr. Ulrich Lang | Vice Director, Head of the Regional Computing Center Cologne |
